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ARPA-H Precision Health ⚡ LIVE Updated: Dec 31, 2025
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Scientific Framework

PATIENT ANALOG

Category-Defining Framework for Human Simulation

The definitive organizational structure for human simulation technologies—integrating digital twins, organoids, organ-on-chip systems, and AI-driven drug discovery into a unified framework aligned with FDA Modernization Act 3.0.

Designation established 2025

FDA Modernization Act 3.0
NIH NCATS Tissue Chip
ARPA-H Precision Health

The Patient Analog Hierarchy

A unified framework positioning human simulation technologies within a clear biological hierarchy—from whole-patient digital twins down to individual organoid cultures.

Designation established 2025

  • The Human The biological reality above all modeling frameworks
  • Patient Analog Apex integration layer—unified, patient-specific simulation
  • System Analog Cardiovascular, immune, metabolic networks as coherent systems
  • Organ Analog Heart, liver, kidney, lung modeled at high fidelity
  • Tissue / MPS Organ-on-chip microfluidic systems with biosensors
  • Organoid Patient-derived 3D cultures that self-organize
The Human
Patient Analog

Patient Analog

The apex integration layer. Combines all subsystems into a unified, patient-specific simulation model.

System Analog

System Analog

Cardiovascular, immune, metabolic, and neuro-endocrine networks operating as coherent physiological systems.

Organ Analog

Organ Analog

Heart, liver, kidney, lung—individual organs modeled at high fidelity for drug response prediction.

Tissue / MPS

Tissue / MPS

Organ-on-chip microfluidic systems with perfusion, biosensors, and electrophysiology integration.

Organoid

Organoid

Patient-derived 3D cell cultures that self-organize into organ-like structures for personalized testing.

Research Hub

Explore the Framework

142 pages of comprehensive research across human simulation technologies

Technologies
Core Technologies

Organ-on-chip, organoids, digital twins, iPSC, microphysiological systems, and NAMs.

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Science
Research & Science

Brain organoids, liver toxicity, cardiac safety, tumor models, assembloids, and more.

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Industry
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Emulate, Organovo, InSphero, Hesperos, Recursion, and leading innovators.

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Regulatory
Regulatory Framework

FDA Modernization Act, NCATS, EPA NAMs, EMA 3Rs, OECD guidelines, global initiatives.

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Market
Market Intelligence

$127B+ TAM, 31% CAGR, funding trends, geographic analysis, and forecasts.

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Domain Portfolio

85 premium domains including PatientAnalog.com, TissueChip.com, OrganoidMedicine.com.

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Intelligence
Resources Hub

500+ curated links: FDA guidance, NIH programs, market research, company profiles, scientific literature.

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Initiate Contact Protocol

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