Design RNA sequences that fold into target secondary structures. Click nucleotide slots to place A, U, G, or C — watch the predicted fold update in real-time and match the target pattern.
Click any position in the sequence strip to cycle through nucleotides: A - U - G - C. Valid base pairs: A-U, G-C, G-U (wobble). Match all target pairs to complete the level.
RNA molecules fold into complex secondary structures through base pairing. These structures are critical for function — ribosomal RNA forms the catalytic core of ribosomes, tRNA adopts cloverleaf structures for amino acid delivery, and mRNA structure regulates translation efficiency. Understanding RNA folding enables design of therapeutic RNAs including mRNA vaccines and CRISPR guide RNAs.