Live News Categories
ORGAN-ON-CHIP
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Microphysiological organ-on-a-chip system for anti-doping research: long-term CYP activity characterization and S107 metabolism in a HepaRG™-based 3D liver model
Engineered Chitosan Nanoparticle Platform Enables Controlled Ibuprofen Delivery and Coordinated Neuroimmune Regulation in a Human Microphysiological Model
Ascending infection of Gardnerella spp. and compartmentalized inflammatory response in fetal-maternal interface organ-on-chip model
Decoding microplastic toxicity on human health: navigating translational challenges using organ-on-chip models
EnView: a tunable microphysiological platform with human crypt-scale topography and independent apical-basal flow for long-term culture and imaging of colonic epithelial monolayers
Integrated "gut-liver"-on-a-chip (iGLoC): an immune-competent and metabolically active microphysiological model of the gut-liver axis for drug screening, validated by abemaciclib pharmacokinetics, hepatotoxicity, and drug-drug interaction studies
Zonation Hallmarks in Human PSC-Derived Hepatic Organoids Integrated into an Immune-Compatible Organ-on-Chip for Liver Injury Modeling
Electrochemical impedance spectroscopy supporting live imaging for barrier assessment in a microphysiological system
Chamber-Design-Associated In Situ Formation of HepG2 Spheroids in a Perfusable Organ-on-a-Chip
Systematic evaluation of deep learning design choices for image-based organ-on-chip quality assessment
Microphysiological models of human gastrointestinal diseases
Engineering human multi-organ tissue chip niches for drug absorption, distribution, metabolism, excretion and toxicity prediction
Advances in engineering organ-on-a-chip models of angiogenesis
Real-time integrated and multiplexed electrochemical sensor for reactive oxygen species in a high-throughput microphysiological system
Sensor-Integrated Organ-on-a-Chip Platforms: Advances in Drug Evaluation and Disease Modeling
Microphysiological Systems Integrating Bioprinting, Organoids, Organ-on-a-Chip, and AI: Next Generation Platforms for Pharmaceutical Development
Artificial intelligence across Organ-on-a-Chip workflows: current implementations and future approaches
Tumor-on-chip and cancer microphysiological platforms: knowledge structure, thematic evolution, and the emergence of organoid-integrated models, 2010-2025
Bridging the gap: using organ-on-a-chip technology to evaluate nanoparticle enzyme replacement therapy for lysosomal storage diseases
Hydrogels and microfluidics: toward more physiologically relevant organ-on-a-chip models
ORGANOIDS
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Human brain organoids reveal MGE interneuron defects independent of mTOR-hyperactivation in genetic focal epilepsy
Characterization of human induced pluripotent stem cell (hiPSC)- derived Kidney Organoids as a Platform to Assess Drug-Induced Nephrotoxicity
Programmable apoptosis circuits enable subtractive engineering of stem cell-derived organoids and embryoids
Modeling ocular tissues with organoids: A review of techniques and applications in lacrimal gland, cornea, lens, and retina organoid
Translational applications and clinical utility of organoids in ovarian cancer: a systematic review
Generation of Spontaneously Beating Neuromyocardial Organoids with Neural Crest-Derived Proprioceptive-Biased Neurons and Real-Time Respirometry
Editorial Expression of Concern: Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture
Automated Spheroid and Organoid Image Analysis from Rule-Based Methods to Deep Learning
Lung Cancer Organoid Models for Studying Resistance to Anti-Angiogenic Therapy: Mechanisms and Applications
Improved quality and reproducibility of cerebral cortical organoids under microfluidic culture conditions: a proof-of-concept study
Multi-omics and spatial analysis of microgravity-grown glioblastoma organoids reveal superior modeling of advanced disease after long-term spaceflight
Self-assembled Carbon Nanotube/Extracellular Matrix Hydrogel as a Promising Matrix for Organoid Growth and Functional Maturation
Modelling herpes simplex virus type 2 and Zika virus replication in mouse vaginal organoids and human vaginal spheroids
CX3CL1 (fractalkine)-CX3CR1 interface drives CD8⁺ T cell-induced neurodegeneration in human brain organoids
An integrated human forebrain organoid reveals microglia-mediated CD8+ T cell recruitment and neuroimmune dysfunction in Alzheimer's disease pathology
Defining GRAMD2 expression in the alveolar epithelium using organoid and single cell approaches
Androgen driven organoids for the male urogenital system
The molecular footprint of valproic acid in human hippocampal organoid
Human iPSC-derived liver organoid model multicellular tissue responses and therapeutic rescue in Wolman disease
Human iPSC-derived lens organoids recapitulate lens development and morphogenesis in vitro
DIGITAL TWINS
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The Role of Digital Twins in Clinical Trials: A New Perspective on Methodological and Statistical Challenges
Sex-based differences in bi-atrial voltage in atrial fibrillation: a multimodal and digital twin approach to distinguish physiological variation from pathological remodelling
Single-cell-level digital twins for preterm birth prevention strategies
Effects of a Generative AI Virtual Patient on Serious Illness Communication Skills: Randomized Controlled Trial
Nonlinear stability phenotypes and collapse dynamics of multi-organ radiomics in total-body PET imaging: toward digital twin-oriented robustness assessment
Q-LCAN: Anatomy-Constrained Quantum-Agentic Systems for MRI-Derived Structural Surgical Digital Twins in Uterine Adenomyosis
Digital twins in hospital operations management: a structured review and quantitative content analysis of decision support, workflow engineering and resource allocation
A Biomanufacturing Digital Twin for Consistent N-1 Seed Bioreactor Transfers for Commercial Monoclonal Antibody Production
From static digital articulation to the dynamic (4D) digital virtual patient: An umbrella review of digital occlusal analysis and jaw-motion tracking
Exploratory bone-brain transcriptomic associations and an ODE-based digital-twin framework for fracture healing
Exploring nursing students' communication experiences with artificial intelligence-supported virtual patients: a qualitative study
Digital twins in toxicology: Toward predictive, personalized and real-time risk assessment
Digital twin validation and predictive value of delta radiomics based on tabular transformer for synergistic muscle imbalance in lumbar disc degeneration
Agent-based simulation and digital twins in heart failure care: Current evidence, validation and implementation barriers
Graph neural network for predicting reentrant drivers in atrial digital twins
Data, Process, and Data-Driven Representations of Digital Twins in Diabetes: Scoping Review
Retrieval-Augmented Simulation for Interpreting Probabilistic Digital Twins in Type 1 Diabetes
Quantum-Inspired Graph Neural Digital Twins for the sub-microsecond topological co-design and temporal degradation modeling of cellulose, hemicellulose, and lignin smart gels
Self-adaptive nanophotonic metasurfaces enabling digital twins: toward continuous personalized healthcare in aging and disability
Digital Twin-Assisted Risk Disclosure in Adults Undergoing Elective Bronchoscopy: Multicenter Randomized Controlled Trial
AI & MACHINE LEARNING
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Development and Evaluation of a Two-Stage Machine Learning Multivariable Model to Support Clinical Decision-Making in Thrombophilia Management
Deep learning-based detection of pneumoperitoneum on computed tomography: performance and clinical feasibility
Machine learning-assisted surface-enhanced Raman spectroscopy technique in dried human blood serum analysis for rapid diagnosis of papillary thyroid carcinoma and central lymph node metastasis
Machine Learning Model Using Clinical and Contrast-Enhanced MRI Features Differentiates Cerebral Tuberculoma from Lung Cancer Brain Metastasis
Machine Learning with Muscle Ultrasound for Osteoporosis Classification: Reporting Discrepancies, Validation, and Clinical Role
Validation of a Computational Histology Artificial Intelligence-based Biomarker for BCG Treatment in Non-muscle-invasive Bladder Cancer in the ANZUP 1301 Randomized Phase 3 Trial
Artificial intelligence in diabetic retinopathy: From deep learning to foundation models, clinical translation, and real-world deployment
Clinical evaluation of deep learning-based acquisition and reconstruction techniques for accelerated 2D shoulder magnetic resonance imaging acceleration at 3 T
From Crystallography to AlphaFold: Artificial Intelligence-Guided Molecular Discovery for Nuclear Medicine Theranostics
Matching clinical claims to evidence for the use of artificial intelligence (AI) in medicine
From Nutritional Epidemiology to Clinical Prediction: Interpretable Machine Learning Reveals Subtle Associations Between Dietary Antioxidant Profiles and Non-Melanoma Skin Cancer in Older Adults
Optimising hospital pharmacy inventory for high-value, intermittent-demand drugs using a machine-learning approach with LightGBM-Tweedie regression: a single-centre, retrospective study
Agentic artificial intelligence for code status extraction from clinical notes: a cross-model comparison of single agent, reflective agent, and multiagent extractor-reviewer system
Vibrational dynamics of TODD-graphene nanosheets via molecular dynamics simulations and machine-learning surrogate models: implications for adaptive nanomechanical devices
Artificial intelligence in diabetes: Clinical applications across the disease continuum
The Current Status and Evaluation of Artificial Intelligence in Bladder Cancer: Clinical Applications and Research
CAPTYN, a Blood-Based Machine-Learning Model Predicting Clinical Benefit of Atezolizumab-Bevacizumab in Hepatocellular Carcinoma: Validation in the IMbrave150 Trial
13 AI drug discovery companies you should know about
‘We’ve been taking our time’: Buzzy AI biotech Xaira reveals antibody platform, first taste of pipeline
‘A plate of spaghetti’: Talus Bio boasts 5,000-fold faster drug screening by skipping protein folding
CLINICAL TRIALS
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STAT+: Novartis multiple sclerosis treatment cuts rates of relapse in pivotal trials
Prilenia and Ferrer secure EU authorisation for Phase III HD trial
Safety and efficacy of lacnotuzumab, a colony-stimulating factor 1 antibody for the treatment of tenosynovial giant cell tumors: a randomized phase II trial
Feasibility of a Co-Designed Personalized Cognitive Reablement Program Delivered via Digital Voice Assistants for Older Adults Living With Early-Stage Dementia or Mild Cognitive Impairment: Pilot Randomized Controlled Trial
Feasibility and Acceptability of Videoconference-Based Family Psychoeducation for Young Adult Caregivers of Family Members With Major Depressive Disorder: Protocol for a Pilot Randomized Controlled Trial
Search for the glycated hemoglobin target minimizing mortality among people with type 2 diabetes with rare incidence of treatment-related severe hypoglycemia - Epidemiologic analysis of J-DOIT3 randomized controlled trial
Ravulizumab in IgA Nephropathy - Interim Analysis of a Phase 3 Trial
Interim Analysis of a Phase 3 Trial of Povetacicept in IgA Nephropathy
Protective effect of N-acetylcysteine on oxaliplatin-induced peripheral neuropathy in colorectal cancer: a randomized controlled trial
Effect of Pain Science Education and Behavioral Graded Activity on Pain in Survivors of Breast Cancer: A Study Protocol for a Multicenter Randomized Controlled Trial
On "Effects of sub-symptom threshold aerobic exercise on persistent postconcussion symptom burden and exercise intolerance: a randomized controlled trial." Valaas LJ, Soberg HL, Rasmussen MS, et al. Phys Ther. 2026;106(6):pzag049. https://doi.org/10.1093/ptj/pzag049
Lynch’s rhPDGF-BB IND secures FDA clearance for Phase II trial
People are taking an unapproved weight-loss drug. AI found something surprising
Auditory Biofeedback Gait Training in Individuals With Chronic Ankle Instability: Protocol for a Randomized Controlled Trial
Cariprazine in the Treatment of Pediatric Patients With Irritability Associated With Autism Spectrum Disorder: A Randomized Controlled Trial
Efficacy of blood flow restriction combined with low-intensity aerobic training in patients with COPD: Study protocol for the BREATH randomized controlled trial
Carbon ion radiotherapy for non-metastatic pancreatic cancer: final results of the prospective phase 2 PACK-study (NCT04194268)
Efficacy and safety of the TRPV1 agonist RTX-GRT7039 in patients with pain associated with knee osteoarthritis: results from a phase 3, randomised, placebo-controlled trial
Author Correction: FcRH5×CD3 bispecific antibody cevostamab in relapsed or refractory multiple myeloma: a phase 1 trial
Carbon nanoparticle-Fe (II) complex for ferroptosis therapy in refractory solid tumors: a phase I trial
REGULATORY
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An update on post-marketing safety signals of sugammadex: A retrospective pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS)
Taxanes versus platinum derivatives for ovarian cancer: a comparative disproportionality analysis using the FDA adverse event reporting system database
Timing of FDA-Defined Adequate BCG Therapy and Oncologic Outcomes in High-Risk Non-Muscle-Invasive Bladder Cancer
Lynch’s rhPDGF-BB IND secures FDA clearance for Phase II trial
FDA approves subcutaneous starting dose for Alzheimer drug
FDA Advisory Committee Recommends Previously Banned Peptides for Compounding
Bridging drug labels and precision medicine: pharmacogenomic opportunities in recent US-FDA drug approvals
A Target Product Profile Framework to Guide Patient-Centered Development, Regulatory Approval, and Market Access of Digital Therapeutics for Substance Use Disorders
GSK Immunotherapy Gets Accelerated FDA Approval for Treating Rectal Cancer
Sirolimus-based immunosuppression and reported rejection or death in heart transplant recipients using the U.S. Food and Drug Administration Adverse Event Reporting System
Food and Drug Administration Grants Ultragenyx's Fayuvi™ First-Ever Approval for Sanfilippo Syndrome Type A Treatment
Real-World Adoption of Adjuvant Immune Checkpoint Inhibition in Stage IIB/IIC Melanoma Following FDA Approval
Comparative Evaluation of Power-Law and Viscoelastic Hemolysis Models in the FDA Nozzle Benchmark Geometry
Malfunction Reporting Patterns in Life-Supporting Versus Noninvasive Ventilators: A Stratified Text-Mining Analysis of the FDA Device MAUDE Database
FDA Approves a Second Weekly Basal Insulin Option for Type 2 Diabetes
FDA Policy Changes on Stability Studies for PET Drugs Manufactured Within Networks
Perspectives on FDA Guidance for Myelodysplastic Syndromes
Evaluation of the accuracy, completeness, and compliance of current summary reporting of adverse events to the Food and Drug Administration using the manufacturer and user facility device experience (MAUDE) database: cross sectional study
Review of embryo-fetal developmental toxicity studies performed for pharmaceuticals approved by FDA in 2024 and 2025
Abbott nabs FDA approval for new CardioMEMS HF System that allows heart readings to be seen at home
DRUG DISCOVERY
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How Omics Technologies Are Transforming Biological Research and Drug Discovery
Synthesis, bioevaluation and structure-activity relationship of podocarpamide derivatives from Zanthoxylum alkaloids (ZAs)
PARP-1 selective inhibitors: A new direction in drug discovery to improve the therapeutic index of PARP-targeted cancer therapy
Structure-activity relationships and mechanisms of natural polysaccharides in modulating kidney diseases via the microbiota-gut-kidney axis: A review
α‑Aminophosphonates in anticancer drug discovery: synthetic strategies, anticancer activities, structure-activity relationships and molecular mechanisms
Ultrasound-assisted deep eutectic solvent extraction of polyphenols from Sophora alopecuroides L. seeds: process optimization, antioxidant evaluation and machine learning-assisted structure-activity interpretation
A new era of GPCR drug discovery: From receptor deorphanization to precision therapeutics
Cell Painting method reveals drug differences in 3D cancer cells
Human Induced Pluripotent Stem Cells in Rare Neurological Disorders: Opportunities and Challenges for Disease Modeling and Drug Discovery
Integrative Metabolomics and Molecular Docking as a Drug Discovery Approach: A Case Study of Microbial Cyclo(Gly-L-Pro) Targeting Alzheimer's Disease
4-Diketopyrrole-2-carboxamide derivatives affecting HBV capsid assembly: structure-activity relationship around the GLP-26 scaffold
Natural products for benign prostatic hyperplasia (BPH): structure-activity relationships and pathway mechanisms
Therapeutic prospects of thiazolo[3,2-b][1,2,4]triazole derivatives: a comprehensive review of biological activities and structure-activity relationship insights
Microwave-assisted combinatorial synthesis of phalloidin derivatives for optimization of structure-activity-relationship (SAR)
Structure-activity relationship (SAR) studies of abaucin derivatives targeting the lipoprotein transport system in Acinetobacter baumannii
13 AI drug discovery companies you should know about
Concept Life Sciences appoints Dr Adrijana Vinter as Chief Executive Officer
Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicity
Evaluating generative models for structure-based drug discovery from de novo design to lead optimization
‘A plate of spaghetti’: Talus Bio boasts 5,000-fold faster drug screening by skipping protein folding
INDUSTRY
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STAT+: Treasury proposes major restrictions to U.S. investment in Chinese biotech sector
Egypt reforms obsolete pharmaceutical pricing framework
Beyond dilation: six biotechs advancing pulmonary hypertension therapies
GLP-1 muscle loss: the next battleground in obesity treatment (Part 2 of 3)
Oncology biotech news: key moves to watch in October 2026
Preclinical Pulse: The research catching our eye in October 2026
Pushing biotech forward in France: 10 companies to know about
ArriVent’s phase 3 lung cancer trial flops, sinking stock
Forbion’s ‘landmark’ €2.3B fundraise to benefit 30 ‘high potential’ biotechs
AstraZeneca hopes to ‘achieve amazing things’ with new Kendall Square R&D center
TRex Bio stomps toward $111M IPO, as Retension and Lycia also gear up to go public
Biotech’s peptide shows promise as ‘bait molecule’ to treat neuropathic pain in mice
Vaxcyte’s stock jumps as pneumococcal vaccine holds its own against Pfizer's, Merck’s shots
Gate CEO sees expanded $870M pact with Lilly as ‘vote of confidence’ in biotech’s platform
‘We’ve been taking our time’: Buzzy AI biotech Xaira reveals antibody platform, first taste of pipeline
Immunotherapy startup Adecto blames ‘risk-averse funding environment’ for closing down
There Is No Such Thing as a Typical Biotech
Otsuka JV recalls one lot of sodium chloride over labeling issue
'Europe does not value what you do': 9 pharmas make urgent call for bloc to beef up innovation muscle
Travere CEO Eric Dube to step down after transforming the rare disease biotech
RESEARCH
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Your blood could reveal inflammatory bowel disease 10 years before diagnosis
Glioblastoma breakthrough reveals how brain cancer cells become more aggressive
Scientists discover a hidden messaging system deep inside the brain
Scientists discover a hidden immune weapon against deadly lung cancer
Scientists discover a surprising secret behind the human brain’s wrinkles
Too much RNA can starve cells of energy, scientists discover
Scientists discover immune pathway behind radiation-induced lung damage
Scientists finally uncover why statins can cause muscle pain
Scientists discover a surprising link between vitamin C and cancer survival
Why painful arthritis can return stronger after cancer treatment
Just 3,000 steps a day may help slow Alzheimer's, scientists find
Magic mushroom ingredient takes the fight out of aggressive fish
Scientists discover that male and female skin play by different rules
Scientists discover how deep sleep builds muscle, burns fat, and boosts the brain
Scientists discover how exercise reverses muscle aging
Scientists discover a surprising danger in smaller cancer cells
Scientists find a surprising genetic twist behind octopus intelligence
Scientists find hidden driver of aging and a simple amino acid that fights memory loss in mice
Scientists discover 5 hidden brain patterns behind depression
A new way to fight gum disease without wiping out good bacteria
TECHNOLOGY
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A Graphene Oxide-Functionalized Fiber Optic Biosensor for Breast Cancer Biomarker Detection: Toward Developing a Highly Sensitive Multi-Fluid Diagnostic Platform
Integrated Droplet Microfluidic Platform for Single-Spheroid Photothermal Nanotherapy and Morphology-Driven Response Prediction
MXene-polydopamine-cyanobacteria photobioelectrochemical biosensor for atrazine detection in environmental waters
An Integrated Cascade-Amplified Microfluidic Biosensor for Reconfigurable Profiling of CRC-Associated Faecal Extracellular Vesicle Surface Proteins
One-pot dual RPA-CRISPR/Cas12a lateral flow biosensor for rapid detection of carbapenemase-producing Klebsiella pneumoniae
Three-dimensional microfluidic nanoprecipitation of zein-loaded polyethylene glycol poly(lactic-co-glycolic acid) nanoparticles with sustained-release antibacterial activity
Transistor Biosensors: A Path to Accessible, Minimally Invasive Early Screening for Alzheimer's Disease
Nonlinear Flow Generation in Microfluidic Impedance Pumps
Machine-learning-integrated NLRC3 and cardiac troponin T dual-analyte lateral-flow biosensor for point-of-care acute coronary syndrome screening and acute myocardial infarction-unstable angina discrimination
Leakage-driven CO2 hydrate growth kinetics from multiphasic CO2 unveiled by high-pressure microfluidics coupled with in situ Raman
Macrocycle-mediated supramolecular regulation of signal transduction in nanoscale biosensors
Microneedle biosensors: from molecular recognition to intelligent diagnostics
PolyJet 3D-printed microfluidic device that integrates hydrodynamic focusing of red blood cells and detection of ATP release
A smartphone-integrated plasmonic biosensor for amplification-free detection of African swine fever virus
Improved quality and reproducibility of cerebral cortical organoids under microfluidic culture conditions: a proof-of-concept study
Genetic Biosensors for High-Throughput Biomedical Applications: Challenges and Advances
A Practical Guide of Choosing and Validating Aptamers for Biosensors
A Sensitive BLE-Enabled Wearable fNIRS Biosensor for Real-Time Monitoring and Mapping of Task-Evoked Oxygen Influxes During On-Screen Cognitive Tasks
HetAnn: Cell Type Annotation for Spatial Transcriptomics by Heterogeneous Graph Learning
Enhanced Lichenysin Production in Bacillus licheniformis by Physicochemical Mutagenesis Combined with High-Throughput Screening
CRISPR & GENE EDITING
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Base editing-mediated exon-specific knockout of glutamine synthetase generates a high-productivity CHO cell line for antibody manufacturing
A phospholipase B effector exploits membrane lipid divergence to drive inter-Bacteroides competition and enables universal genome editing
On-Site, Highly Sensitive, and Multisignal Detection of Cucumber Bacteria via CRISPR/Cas12a Coupled with Duplex Recombinase Polymerase Amplification
One-pot dual RPA-CRISPR/Cas12a lateral flow biosensor for rapid detection of carbapenemase-producing Klebsiella pneumoniae
Transcriptomics of independent CRISPR-edited cell lines reveal ciliary-specific ARL13B dependent changes
An aptamer-regulated CRISPR/Cas12a system based on split crRNA for theophylline and tobramycin detection
Decadal Spatiotemporal Dynamics and Genetic Diversity of Erwinia amylovora in China (2016 to 2025) Revealed by CRISPR Genotyping
Pooled CRISPR screens identify genes and non-coding genomic regions that regulate red blood cell density
Target-triggered exponential amplification-enhanced CRISPR/Cas12a system with a fluorescence-quenching lateral flow assay for ultrasensitive detection of Salmonella typhimurium
A phage-encoded small RNA that mimics chimeric guide to inhibit CRISPR-Cas9
Great gene editing. Now prove it without overcomplicating the analysis
Structural basis for loop-dependent inhibition by AcrIIC1 anti-CRISPR proteins
Author Correction: UNCOVERseq enables sensitive and controlled gene editing off-target nomination across CRISPR-Cas modalities and systems
A cryptic binding pocket regulates the metal-dependent activity of Cas9
Manipulating rRNA levels with CRISPR
Correction: CRISPR/Cas9-mediated gene correction of Wilson disease H1069Q point mutation in patient-specific induced pluripotent stem cells
Site-specific RNA photocrosslinking of CRISPR-associated and viral RNA-binding proteins using genetic code expansion
Bigger than CRISPR? A guide to the latest genome editors
CRISPR-based gene drive systems alter the transcriptome in Anopheles gambiae mosquitoes
CRISPR could help doctors attack blood cancer without destroying healthy cells
CELL & GENE THERAPY
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Nearly one third of patients with advanced melanoma saw tumors disappear completely after receiving TIL therapy plus pembrolizumab immunotherapy
CAR T cells targeting fibroblast activation protein-α for the treatment of pulmonary fibrosis
STAT+: Patient dies in Bristol Myers Squibb autoimmune CAR-T trial
Determinants of response to CAR T cell therapy in a multicenter, multi-trial cohort analysis of patients with lymphoma
CD8 T-cell exhaustion linked with CAR T-cell failure can be mitigated by a non-alpha IL2 receptor agonist
T Cell Receptor-Engineered T Cell Therapy in Solid Tumors: Where We Stand and What's to Come
Alcon Expands Its Cell Therapy Ambitions With $550M Neurotech Pharma Acquisition
Translation of in vivo CAR-T in China
Second Primary Malignancy in Patients with DLBCL Receiving CAR T Therapy and Other Systemic Anticancer Therapy: Real-World Evidence from a Large US National Claims Database
ROR2-expressing acute myelogenous leukemia cells can be selectively targeted by anti-ROR2 CAR T cells
Predictors and Outcomes of Immune Effector Cell Associated Neurotoxicity Syndrome in Patients Receiving Chimeric Antigen Receptor T Cell Therapy for Aggressive B-Cell Non-Hodgkin Lymphoma
Cardiovascular Toxicity Across the Cancer Immunotherapy Spectrum: Mechanisms and Management in Immune Checkpoint Inhibitor (ICI) and Chimeric Antigen Receptor T-Cell (CAR-T) Therapy
Pityriasis rosea following CAR-T cell therapy: possible non-HIV immune reconstitution inflammatory syndrome
FAP-targeting CAR T cells with constitutive IL-10 expression reduce kidney fibrosis in mice
Localized hydrogel depots for CAR-T cell therapy in solid tumors: materials design, cellular fitness and translational deployment
Domain Shuffling Builds Synthetic Genes that Boost CAR T-Cell Design
Scientists reprogram immune cells inside the body to fight cancer
Novartis pens $7.8B deal for Abogen's in vivo autoimmune T-cell engager
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases
Author Correction: Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells
BIOPRINTING
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Enhancing the Structural Integrity of 3D Bioprinted Urethral Grafts for Clinical Applications using GelMA-Fibrinogen Bioinks Infused with Human Primary Cells
Accelerated Formulation Screening of Multi-Component Bioinks via a Deep Learning-Integrated High-Throughput Gradient Printing Platform
Fungal-Derived Chitosan-Based Bioinks Enable Multifunctional Musculoskeletal Tissue Engineering via Enhanced Bioactivity
Granular hydrogel bioink for macroporous pancreatic spheroid scaffolds
Biofabrication of osteochondral composite scaffolds: advances in multi-material bioprinting, functional microenvironment engineering and orthopedic translation
A multi-component polymeric bioink formulation developed using an in-house integrated bioextruder
3D-bioprinted dual-factor nerve conduits promote neurovascular co-regeneration via activation of the PI3K/AKT and MAPK/ERK pathways
Enzymatic cross-linking collagen-based bioink for 3D bioprinting of endometrial model with endometrial epithelial organoids
Emerging Strategies for Bioprinting Organized Musculoskeletal Tissues with Biomimetic Collagen Architecture
Airflow controlled droplet bioprinting enables high-throughput generation of iPSC-derived thymic organoids within vivoT cell functionality
Next-generation hydrogels and strategies to recreate 3D tumour microenvironments for osteosarcoma: from bioprinting to therapeutic testing
Protocol for fabricating immune-regulatory bone organoids via plant-based bioinks
3D bioprinting and scaffold technology applications for the management of lung diseases
3D bioprinted porous PLLA implants with dual gene modified BMSCs for osteoarthritis cartilage repair
Cell-Laden 3D-Bioprinted Artificial Skin Grafts for Tissue Engineering Wound Healing
MLATE V3: An Open-Source Multi-Tissue AI Framework for Data-Driven Optimization of 3D-Printed and Bioprinted Scaffolds
3D bioprinting in dermatological therapeutics: Technologies, applications, and clinical perspectives
Spatially Controlled Release from Printable Microgels for Embedded Bioprinting
PRECISION MEDICINE
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Gradient-driven microfluidic framework for the screening of ratiometric drug combinations towards precision oncology in paediatric leukaemia
Networked innovation in the new modality era: strategic insights from spin-offs and precision medicine
Readiness for precision medicine: pharmacogenomic literacy among adults surveyed in the United Arab Emirates: a cross-sectional study
Advances in Single-Cell and Spatial Omics for Glioblastoma Precision Medicine
The right patient, the right moment, the right therapy: reimagining precision oncology from the bedside
Evaluation of a pharmacist-led pharmacogenomic service and provider acceptance at VA Puget Sound
Bridging drug labels and precision medicine: pharmacogenomic opportunities in recent US-FDA drug approvals
Response Letter: ACE Inhibition in PH-COPD: Severity Stratification Unlocks a Precision Medicine Opportunity
Precision oncology in advanced melanoma: molecular landscapes and personalized therapy recommendations from the Molecular Tumor Board Freiburg
Advancing functional treatment prediction for precision oncology
Biologicals at the Allergy-Cancer Interface: Advancing AllergoOncology Through Bidirectional Precision Medicine-An EAACI Editorial
The ESMO Scale for Clinical Actionability of Molecular Targets, version 2 (ESCAT v2): an evidence-based framework for ranking alterations as actionability and resistance biomarkers in precision oncology
Biologics in alopecia areata: promise, paradox, and the precision medicine frontier
Feasibility of a personalised medicine clinic for children with asthma: the PRISTINE 2 study
Revisiting Ehrlich carcinoma in the era of precision oncology: bridging classical models with modern systems biology
Emerging Role of AI in Single-Cell Sequencing Toward Biomarker Discovery, Therapeutic Target Identification and Precision Medicine in Lung Cancer
Population pharmacogenomics of CYP1A2, CYP2C19, CYP2D6 and CYP3A4 in a Uruguayan cohort with schizophrenia
Biomarker-guided targeted therapy in lung adenocarcinoma: A concise review of precision oncology advances, resistance mechanisms, and emerging strategies
From Paracelsus to Precision Medicine: Paediatric Epilepsy as the Paradigm of Individualized Therapy
An imprecise label in the era of precision medicine: labelling and access for daraxonrasib, the first pan-RAS inhibitor approval
STEM CELLS
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Characterization of human induced pluripotent stem cell (hiPSC)- derived Kidney Organoids as a Platform to Assess Drug-Induced Nephrotoxicity
Are 5G radiofrequency electromagnetic fields and PARP1 interfering in the development of human iPSC-derived dopaminergic neurons?
Electrophysiological remodeling in the hypertrophic cardiomyopathy MYBPC3 R943X mutant in human iPSC-derived cardiomyocytes and modulation by IKto-targeting drugs
Human Induced Pluripotent Stem Cells in Rare Neurological Disorders: Opportunities and Challenges for Disease Modeling and Drug Discovery
Exploring the therapeutic potential of human iPSC-NPC-based therapy in MPS IIIA
A novel strategy to generate human iPSCs with enhanced mesodermal and endodermal differentiation capacity
HER2 CAR-expressing iPSC-derived iNKT cells exhibit multifaceted immunomodulatory functions beyond direct tumor killing
Spheroid-based generation of 3D myogenic tissues using transgene- and sorting-free differentiation of hiPSCs
Genetically Defined Acute Myeloid Leukemia Induced Pluripotent Stem Cell Clones Reveal Selective Impairment of Hematopoietic Development
Chemical reprogramming of human pluripotent stem cells into 8-cell-like states
The prognostic impact of CEBPA mutation in acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation
Ketamine induces synaptic and monoaminergic remodeling in human iPSC-derived neurons
Human iPSC-derived liver organoid model multicellular tissue responses and therapeutic rescue in Wolman disease
Generation of Spinocerebellar Ataxia 27B iPSC Lines and Isogenic Controls
IL-12-producing iPSC-derived antigen-presenting cells enhance antitumor immunity and enable off-the-shelf immunotherapy
AI-integrated iPSC multi-omics: advancing phenotype discovery and drug target identification in rare diseases
Human iPSC-derived lens organoids recapitulate lens development and morphogenesis in vitro
Inhibition of endogenous TGF-β normalizes extracellular matrix deposition in hiPSC-derived fibroblasts
New signaling pathway enhances blood stem cell transplantation outcomes
Correction: CRISPR/Cas9-mediated gene correction of Wilson disease H1069Q point mutation in patient-specific induced pluripotent stem cells
NEW APPROACH METHODS
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Integrating New Approach Methodologies (NAMs) into Read-Across Evidence Streams for Short-Chain Nitroparaffins
Evaluating the biological effects of caffeine-related compounds methylliberine and theacrine by integrated in silico and in vitro new approach methods (NAMs)
New approach methodologies in nanomedicine: bridging the gap between in silico, in vitro, and in vivo systems
A novel double-mAb sandwich ELISA utilizing broad-spectrum neutralizing antibodies as an in vitro alternative to the rabies vaccine NIH potency assay
Towards the One Exposome: harnessing artificial intelligence and digital health technologies across One Health toxicology, new approach methodologies, and environmental public health
Animal Models for Interventional Oncology Research: Overview and Considerations in the Era of New Approach Methodologies
An overview of In vitro genotoxicity testing strategies for fragrance materials: Addressing false positives and advancing non-animal approaches
New approach methodologies to model the female reproductive tract: advances and opportunities for nanomedicine
Advancing component-based mixture risk assessment using new approach methodologies: An environmental case study
Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report
New approach methodologies in pharmaceutical development: Survey insights on adoption, infrastructure, and the path to broader implementation
Quinoa and Peanut Extracts as Alternatives to Animal-Derived Extracellular Matrix Proteins in Cultured Meat Production
Editorial: Shaping the future of predictive toxicology: addressing challenges and new approach methodologies
Engineering 3D neural models of neurodegeneration: the Neural Microenvironment Design Code (NMDC), design principles, and emerging new approach methodologies
New approach methodologies for in vitro detection of chemical-induced cholestatic liver injury
Human placental transfer of xenobiotics in health and disease: New approach methodologies for developmental and reproductive toxicology testing and mathematical modelling
AI-integrated human-relevant alternatives to animal experimentation in drug development: Toward a predictive translational ecosystem, from in vitro and in silico models to clinical and real-world evidence
New approach methodologies: drug screening platform to identify antifibrotic compounds
Strategic application of New Approach Methodologies (NAMs) in fragrance ingredient safety assessment: Integration of in vitro, in silico, and exposure-based approaches in RIFM evaluations
FUNDING & VC
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STAT+: AI drug firm Pathos raises $237 million, pushing valuation to $3 billion
Alcon Expands Its Cell Therapy Ambitions With $550M Neurotech Pharma Acquisition
Merck KGaA’s $1.1B Silence Therapeutics Buyout Brings RNA Drug for Rare Blood Cancer
City Therapeutics’ Upsized IPO Raises $200M to Bring RNAi Drugs Beyond the Liver
RougeTx launches with $58 million series A financing for HHT therapy
IMMUNOTHERAPY
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Nearly one third of patients with advanced melanoma saw tumors disappear completely after receiving TIL therapy plus pembrolizumab immunotherapy
Celltrion and Kaigene sign $580m licence deal for KG013
Extracorporeal photopheresis for the treatment of steroid-refractory immune related adverse events from immune checkpoint inhibitor therapy: a multi-center phase Ib/II clinical trial
Impact of Administration Timing of Immune Checkpoint Inhibitors in Metastatic and Advanced Non-small Cell Lung Cancer: Systematic Review and Updated Meta-Analysis
Citrullinated histone H3 and elevated polyamine metabolism gene expression in peripheral blood polymorphonuclear leukocytes as biomarkers for poor immunotherapy response in cancer patients
Patients' lived experiences of fractures during immune checkpoint inhibitor therapy: a qualitative study
Biomarkers and future directions for immunotherapy in microsatellite-stable colorectal cancer: a systematic review
Unstable immune cells linked to severe cancer immunotherapy side effects
Association of pre-existing cardiovascular disease with cardiovascular and clinical outcomes in patients receiving immune checkpoint inhibitors
Incidence and clinical impact of venous thromboembolism during immunotherapy for gynecologic cancer
Intron retention regulates STAT2 function and associates with immunotherapy response in lung cancer
GSK Immunotherapy Gets Accelerated FDA Approval for Treating Rectal Cancer
Jemperli Could Let Some Rectal Cancer Patients Skip Chemotherapy, Radiation And Surgery
Why painful arthritis can return stronger after cancer treatment
Author Correction: FcRH5×CD3 bispecific antibody cevostamab in relapsed or refractory multiple myeloma: a phase 1 trial
In vivo engineering of CAR natural killer cells for immunotherapy using ligand-directed lipid nanoparticles
Bowel cancer “melted away” after immunotherapy, then stayed away
Cancer-fighting t cells burn out. Scientists may have found a fix
Genmab’s latest phase 2 data spur claim ADC is ‘clearly superior’ to AbbVie’s Elahere
Immunotherapy startup Adecto blames ‘risk-averse funding environment’ for closing down
MICROBIOME
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Dietary Equisetum arvense Polysaccharides Alleviate Obesity in Aged Mice Associated with Altered Gut Microbiota
Gut virome remodeling after fecal microbiota transplantation is associated with virus-bacteria co-variation and metabolic response in obesity and type 2 diabetes
Exploring urogenital microbiome differences in children with and without overactive bladder: first approach
Targeting the gut-liver axis and gut microbiome in pediatric metabolic dysfunction-associated steatotic liver disease: current evidence and future directions
Zhuhuang Granules alleviate psoriatic inflammation via restoring gut microbiota balance and enhancing intestinal barrier integrity
Oral versus intranasal probiotics for nasal microbiome modulation: a comparative review of route-dependent mechanisms and clinical implications
Unstable immune cells linked to severe cancer immunotherapy side effects
Bovine keratoconjunctivitis: a review of the bovine ocular surface microbiome and related epidemiological risk factors
Ineupatorolide B Alleviates Postpartum Depression-Like Behaviors via the Gut Microbiota-Butyrate-Brain Axis
Effects of social rearing systems on the gut microbiome of dairy calves before and after weaning
Gut microbiome dysbiosis and alterations in kynurenine pathway of tryptophan metabolism are associated with depression in people with HIV
Structure-activity relationships and mechanisms of natural polysaccharides in modulating kidney diseases via the microbiota-gut-kidney axis: A review
From Microbiome Profiling to Clinical Translation: Designing microbiome studies for clinical actionability
Infant gut microbiome neuroactive pathways link to social disadvantage, toddler neurodevelopment, cognitive and behavioural outcomes: a longitudinal cohort study
Gut microbiota-derived indole-3-acetic acid ameliorates necrotizing enterocolitis-induced adolescent-stage cognitive impairment via regulating AHR-mediated neuroinflammation and synaptic structural integrity
Disentangling microbiota-dependent and -independent impacts of antibiotics on host physiology
Publisher Correction: Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy
Discovering gut microbiome signatures that predict adverse and reverse cardiac remodeling in preclinical heart failure
Genome mining of the tumor microbiome reveals biosynthetic diversity and potential pathology-modulating metabolites
Sugar-rich foods exacerbate antibiotic-induced microbiome disruption
CARDIOVASCULAR
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Dose-Response Associations of Exercise Modalities With Cardiorespiratory Fitness in Heart Failure: A Systematic Review and Bayesian Network Meta-Analysis
Current aspects in surgical treatment of advanced heart failure with future durable mechanical circulatory support
Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure
Advanced Subclinical Atherosclerosis in Young Individuals and Risk of Mortality Over 30 Years: The Coronary Artery Calcium Consortium
Global Heart Failure Burden Increased Between 1990 and 2023
Arrhythmic Risk Stratification in Non-Ischaemic Cardiomyopathy: The Role of Cardiac Magnetic Resonance Imaging
Pacing Rate Acceleration in Right-Sided Heart Failure: Insight From an On-Off-On Clinical Course
Three ablation strategies using very high-power short-duration catheter in paroxysmal atrial fibrillation: The Q-INDEX randomized trial
Pericoronary Inflammation With and Without Atherosclerosis: Marker, Mediator, or Both?
Intravenous Iron Supplementation in Heart Failure with Preserved Ejection Fraction: A Systematic Review
Co-Designing a Digital Platform for the Management of Modifiable Risk Factors and Comorbidities in Patients With Atrial Fibrillation: Mixed Methods Usability Study
Electrophysiological remodeling in the hypertrophic cardiomyopathy MYBPC3 R943X mutant in human iPSC-derived cardiomyocytes and modulation by IKto-targeting drugs
Mapping cellular senescence in heart failure: knowledge evolution, mechanistic modules, and senotherapeutic opportunities
Design and rationale of a multicenter randomized trial assessing strategies for catheter ablation of persistent atrial fibrillation- The STAR AF 3 trial
Pulmonary Vein Isolation With Contact-Force-Sensing Large-Tip Focal Pulsed Field Ablation Catheter With 3D Mapping for Paroxysmal Atrial Fibrillation: Omny-IRE 12-month Results
CATHETER ABLATION VERSUS SHAM FOR SYMPTOMATIC ATRIAL FIBRILLATION: A SYSTEMATIC REVIEW AND BAYESIAN META-ANALYSIS OF RANDOMIZED TRIALS
Non-Invasive Stimulation of the Median Nerve: Neuromodulation to Reduce Atrial Arrhythmias in Paroxysmal Atrial Fibrillation (The Randomized BEAT-AF Pilot Study)
Undiagnosed Arrhythmogenic Cardiomyopathy Hidden in Explanted Hearts: Insights from a Single Tertiary Center
Mitral Valve Prolapse and Ventricular Arrhythmia Risk in TTN-Mediated Cardiomyopathy: A Single Center Experience
Powerful cholesterol drug cuts heart attack risk by 31%
ONCOLOGY
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FOXC1–GMDS axis-driven glycolytic reprogramming promotes tumor progression in triple-negative breast cancer
STAT+: Most cancer drugs approved by European regulators lack a high clinical benefit, analysis finds
STAT+: Pharmalittle: We're reading about a cancer vaccine, an experimental pancreatic cancer drug, and more
Dual-targeted therapy shows promise against metastatic triple-negative breast cancer
Scientists discover a hidden immune weapon against deadly lung cancer
Lumbar fenestration to avoid shunting after posterior fossa tumor resection and failed ventriculostomy clamp trial
A Calcium-Overloading MOF Platform with Cuproptosis for Cancer Therapy and Inhibition of Cancer Cell Growth and Migration
CASTOR1 functional inactivation drives KRAS-mutant NSCLC and therapy resistance by a noncanonical mechanism of tumor suppression
Smoking Status and Response to Total Neoadjuvant Therapy for Rectal Cancer: A National Cohort Study
Association between cancer cachexia and treatment-related adverse outcomes in patients with gastrointestinal cancers: a systematic review and meta-analysis
Protective effect of N-acetylcysteine on oxaliplatin-induced peripheral neuropathy in colorectal cancer: a randomized controlled trial
Clinical response outweighs baseline nodal stage in treatment selection and survival of clinically node-positive bladder cancer
p300 activity and subcellular localization associate with tumor aggressiveness and clinical outcome in triple-negative breast cancer
Jemperli Could Let Some Rectal Cancer Patients Skip Chemotherapy, Radiation And Surgery
Why painful arthritis can return stronger after cancer treatment
The conformation-selective PI3Kδ inhibitor roginolisib in patients with advanced or metastatic cancer, including metastatic uveal melanoma: first-in-human clinical trial
Scientists just found a way to fight lung cancer and muscle wasting at the same time
Vitamin D drug may help crack pancreatic cancer’s protective shield
Scientists say house cats could help unlock better cancer treatments for humans
A major risk of breast cancer screening may have been overestimated for decades
NEUROSCIENCE
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Liquid-liquid phase separation in neurodegenerative diseases: Mechanisms, pathological transitions, and therapeutic opportunities
Lipid synthesis, transport, and metabolism in oxidative stress and neuroinflammation for neurodegenerative diseases
Cannabidiol in Alzheimer's disease: evidence-weighted molecular mechanisms and translational challenges
STN-SNr co-stimulation in Parkinson's disease: a systematic review and meta-analysis of motor and freezing-of-gait outcomes
Metabolic Dyshomeostasis, neuroinflammation, and glymphatic clearance deficits as convergent drivers of Alzheimer's disease: an exposome-based conceptual framework for prevention
Clinimetrics of the Shortened Frontal Assessment Battery (FAB15) in Neurodegenerative Disorders
Receptor-Specific ER-Phagy in Neurodegenerative Diseases: Molecular Mechanisms and Emerging Therapeutic Opportunities
Promoting KAT5-Mediated CUL5 Lactylation to Downregulate MAVS/NLRP3 Signaling in the Hippocampus: The Novel Mechanisms Underlying Hydrogen Sulfide-Ameliorated Cognitive Dysfunction in Parkinson's Disease
NEFL contributes to DJ-1-mediated neuroprotection and autophagic flux regulation in Alzheimer's disease-like injury
Transistor Biosensors: A Path to Accessible, Minimally Invasive Early Screening for Alzheimer's Disease
Multi-omics analysis of potential therapeutic targets for Alzheimer's disease and associated differences in immune cell infiltration
Dissociable associations of free-water fraction and DTI-ALPS index with disease manifestation and mutation carrier status in Parkinson's disease
Design and Synthesis of Novel β-Naphthol Dithiocarbamate Hybrids: A Convergent Multifaceted Approach Towards AChE and Amyloid-β Inhibition for Alzheimer's Disease
MiR‑204‑5p modulates glial morphology and apomorphine‑induced rotational asymmetry without dopaminergic neuroprotection in a preclinical mouse model of Parkinson's disease
Locus coeruleus abnormalities on neuromelanin-sensitive MRI in Parkinson's disease: a systematic review and meta-analysis
Cell Painting method reveals drug differences in 3D cancer cells
"Mind-blowing" Alzheimer’s breakthrough: Two hours of sleep restored without clearing brain plaques
Scientists may have overlooked a hidden Alzheimer's culprit for decades
The hidden math of Alzheimer's could point to new treatments
Genentech pays Alector $100M for preclinical Parkinson’s prospect
INFECTIOUS DISEASE
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Linear cap-independent mRNA vaccines as an emerging vaccine platform
Moderna mRNA vaccine almost halves the risk of skin cancer returning
Frontline Staff Vaccine Communication During Pediatric Well-Child Encounters: A Mixed-Methods Study
Immunogenicity and Safety of PHH-1V COVID-19 Vaccine as a Heterologous Booster in Adolescents
Immunoinformatics and reverse vaccinology design of self-amplifying RNA vaccine against marburg virus with structural dynamics and immune simulation analysis
Changes in attitudes toward the HPV vaccine in Kenya
Anthropocentric Thinking about Antibiotic Resistance and Ecosystems: Relations between Explanations and Misconceptions in American Undergraduates from Urban and Rural Backgrounds
Cross-sectional analysis of pneumococcal conjugate vaccine immunity in infants from the community
Photodynamic inactivation and photodynamic therapy for viral pathogens: a systematic review of antiviral efficacy, mechanisms, and translational boundaries
Efficacy and economic evaluation of a novel genotype VII marker vaccine for Newcastle disease in layers
Source-related patterns and ecological risk prioritization of antibiotics in a large lake-river system: insights from the Poyang Lake Basin
Eugenol Activity Against Escherichia coli and Staphylococcus aureus: Biofilm Disruption and Additive Interactions with Antibiotics
Exploring spillovers of vaccines: A practical application of the Expanded Impact Inventory
Osivax reports phase 2b data for OVX836
High-risk antimicrobial resistance genomic traits in multidrug-resistant Salmonella across China’s food chain: projections to 2050
Safety and immunogenicity of a BPL-inactivated, whole-virus, universal influenza vaccine: a randomized, double-blinded, double-dummy, placebo-controlled, phase 1 clinical trial
Bioengineering strategies for improving the immunogenicity of mRNA vaccines
160-million-year-old proteins show surprising power against superbugs
AI-guided optimization for thermostable mRNA vaccines
Recoding by N1-methylpseudouridine guides rational mRNA vaccine design
LIQUID BIOPSY
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Inferring tissue origin from cell-free DNA in metastatic cancer
Attitudes of cancer patients toward ctDNA-based liquid biopsy for follow-up
Diagnostic Performance of cfDNA-Based Liquid Biopsy for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis
Integrated microfluidic platform for the capture and identification of circulating tumor cells using dielectrophoresis and image recognition
Extended Non-Invasive Prenatal Testing for Chromosomal and Monogenic Disorders by Cell-Free DNA Sequencing: A Blinded Comparison With Amniocentesis
Paxalisib with Trastuzumab for HER2-Positive Metastatic Breast Cancer with Active Brain Metastases: A Phase II Trial with Integrated Plasma and CSF ctDNA Analyses
A nine-year CLIPPERS-like syndrome at the boundary of CNS T-cell lymphoproliferation: clinicopathological and CSF cell free DNA findings
Multi-omics liquid biopsy for leptomeningeal metastases in lung cancer: from molecular mechanisms to precision diagnosis and treatment
Prognostic value of circulating tumor DNA in esophageal and gastric cancer by treatment stage: A systematic review and meta-analysis
Profiling circulating tumor DNA for recurrence prediction and prevention in hepatocellular carcinoma following liver transplantation
Value and research advances of ctDNA in perioperative therapy for non-small cell lung cancer
Circulating citrullinated proteins as candidate liquid biopsy analytes in cancer
Cell-free DNA fragmentomics and epigenomic profiling in hematologic malignancies: current evidence, translational limitations, and future directions
Whole Genome Sequencing-based tumor-informed circulating tumor DNA monitoring for early detection of recurrence in patients with solid tumors
Decoding coupled epigenetic-fragmentomic signals in circulating cell-free DNA for interpretable cancer diagnosis
Correspondence: Interpreting Hazard Ratios in Meta-Analyses on ctDNA in Colorectal Cancer
Cell-free DNA methylation markers in the diagnosis of hepatitis B virus-related- hepatocellular carcinoma: a review
Integrated Viscoelastic Microfluidics for Label-Free Separation and Concentration of Circulating Tumor Cells
Liquid biopsy cell analysis and ex vivo culture as effective methods of therapeutic indexing of metastasis in B[a]P-induced lung cancer mice for an active targeted quercetin therapy
ctDNA retesting to guide anti-EGFR therapy in later-line metastatic colorectal cancer