A New Regulatory Era

The FDA Modernization Act 3.0 represents a fundamental shift in drug development, removing the animal testing mandate and officially recognizing New Approach Methodologies (NAMs) as valid alternatives. Our platform is built from the ground up to generate regulatory-ready data aligned with this new paradigm.

FDA Modernization Act 3.0 Key Points

  • Removes requirement for animal testing before human trials
  • Explicitly authorizes use of NAMs (organ-on-chip, organoids, computational models)
  • Requires FDA to accept NAMs data when scientifically appropriate
  • Enables faster, more human-relevant drug development pathways

Regulatory Framework Support

FDA

FDA MAA 3.0

Full compliance with FDA Modernization Act requirements for NAMs-based submissions, including data format, validation, and documentation standards.

ICH

ICH Guidelines

Alignment with ICH S5 (reproductive toxicity), S7 (safety pharmacology), and M7 (mutagenicity) guidelines for harmonized global submissions.

EMA

EMA 3Rs

Support for European Medicines Agency 3Rs principles (Replacement, Reduction, Refinement) and acceptance of alternative methods.

OECD

OECD Test Guidelines

Compliance with evolving OECD guidelines for in vitro testing methods, defined approaches, and integrated testing strategies.

Built-In Compliance

Audit Trails

Complete, immutable records of all data generation, processing, and analysis steps meeting 21 CFR Part 11 requirements.

Validation Packages

Pre-built IQ/OQ/PQ documentation, reference compound benchmarking, and method validation protocols.

CDISC Standards

Native export to SEND (nonclinical) and SDTM (clinical) formats for direct regulatory submission integration.

Data Security

SOC 2 Type II certified infrastructure with encryption at rest and in transit, role-based access control, and HIPAA compliance.

Regulatory Submission Support

Study Reports

Automated generation of GLP-style study reports formatted for IND/NDA/BLA submissions.

Method Qualification

Documentation packages demonstrating fit-for-purpose qualification of NAMs assays.

Regulatory Strategy

Expert consultation on integrating NAMs data into regulatory submission strategies.

Agency Meetings

Support materials for pre-IND meetings and regulatory agency discussions about NAMs approaches.