A New Foundation
A Patient Analog is the unified biological-computational representation of human physiology, integrating organoids, microphysiological systems, organ-on-chip platforms, multi-omics, and simulation engines into a single modeling substrate.
This framework establishes a hierarchical structure progressing from foundational biological substrates to fully integrated, simulation-ready human models. Each tier builds upon the complexity and integration of the previous, creating a comprehensive system for human-relevant drug discovery.
The Seven Tiers
The Human
The biological reality that all modeling frameworks ultimately seek to represent and predict.
Patient Analog
Integrated bio-digital model of a complete human individual for personalized simulation.
Digital Twin
Computational patient simulation platform integrating multi-omic data for predictions.
System Analog
Multi-organ physiological subsystems modeling interconnected organ functions.
Organ Analog
Individual organ modeled at high fidelity with full functional representation.
Tissue / MPS
Engineered microphysiological systems recreating tissue-level biology.
Organoid
3D cell cultures that self-organize to mimic organ structure and function.
Institutional Alignment
Explore the Platform
Discover how the Patient Analog Framework powers real-world drug discovery applications.