What is an Organ Analog?
An Organ Analog represents a complete, high-fidelity model of an individual human organ. This tier integrates multiple tissue types, vascular networks, and functional units to capture the full complexity of organ-level physiology. Organ Analogs can predict drug effects, toxicity, and disease progression for specific organs.
Liver Analog
Complete hepatic model with zonation, bile production, CYP450 metabolism, and drug-induced liver injury endpoints.
Heart Analog
Cardiac model with contractility, electrophysiology, hERG channel function, and cardiotoxicity assessment.
Kidney Analog
Nephron model with filtration, secretion, reabsorption, and nephrotoxicity prediction capabilities.
Lung Analog
Pulmonary model with alveolar-capillary barrier, breathing mechanics, and inhalation drug delivery.
Organ-Level Completeness
Tier 3 achieves complete organ-level representation. While previous tiers model tissues and tissue systems, the Organ Analog captures all the complexity needed for organ-specific predictions. This is the level at which most drug toxicity and efficacy assessments become possible.