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GHS Classification & NAMs
The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) provides standardized hazard communication worldwide. GHS classifications increasingly accept data from New Approach Methodologies, particularly for skin sensitization, eye irritation, and acute toxicity endpoints.
Global Impact: GHS is implemented in over 70 countries. NAMs data accepted under GHS criteria gains international recognition, reducing testing requirements across multiple markets.
GHS Hazard Categories Accepting NAMs
| Endpoint | GHS Category | Accepted NAMs |
|---|
| Skin Sensitization | Category 1, 1A, 1B | DPRA, KeratinoSens, h-CLAT, LLNA alternatives |
| Eye Irritation | Category 1, 2A, 2B | BCOP, ICE, EpiOcular, RhCE |
| Skin Corrosion | Category 1A, 1B, 1C | EpiSkin, EpiDerm, SkinEthic |
| Acute Toxicity | Categories 1-5 | 3T3 NRU for oral LD50 estimation |
Benefits of NAMs for GHS Classification
- Human Relevance - Human cell-based assays provide species-relevant data
- Defined Approaches - Multiple NAMs combined for confident classification
- Speed - Faster classification compared to animal testing
- Cost Efficiency - Lower testing costs for chemical manufacturers
- Ethical - Alignment with 3Rs principles and public expectations
Implementation by Region
- EU CLP - Full NAMs acceptance for skin/eye endpoints
- US OSHA HCS - Aligned with GHS, accepts validated alternatives
- Japan JIS - Increasing NAMs acceptance
- China GB - Evolving toward NAMs integration
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Educational content created by J Radler for the biotech and scientific community. Last updated: February 4, 2026.
Free to share for educational purposes with attribution.