CNS DRUG DEVELOPMENT CHALLENGE
CNS drugs have the highest clinical trial failure rate of any therapeutic area (~95%), largely due to the blood-brain barrier limiting drug delivery and poor translation from animal models. Human brain organoids and BBB-chips are transforming CNS drug discovery by providing human-relevant models.
PLATFORM TYPES
- Brain Organoids: Cerebral organoids with cortical layering
- BBB-Chip: Emulate blood-brain barrier permeability model
- Assembloids: Multi-region brain circuit models
- Nerve-on-Chip: AxoSim myelinated axon platforms
KEY APPLICATIONS
- BBB Penetration: Drug permeability and efflux transporter testing
- Alzheimer's Disease: Amyloid and tau pathology modeling
- Parkinson's Disease: Dopaminergic neuron degeneration
- Neurodevelopment: Autism, schizophrenia, Zika virus effects