NEPHROTOXICITY CHALLENGE
Drug-induced kidney injury accounts for 20% of acute kidney injury cases and is a major cause of clinical trial termination. The kidney's complex transporter systems and susceptibility to toxic metabolites make it particularly challenging to model, driving demand for human-relevant platforms.
PLATFORM TYPES
- Kidney-Chip: Emulate proximal tubule model with fluid shear stress
- Kidney Organoids: Nephron structures with glomeruli and tubules
- OrganoPlate: Mimetas high-throughput proximal tubule screening
- Bioprinted Kidney: Organovo functional tissue constructs
KEY APPLICATIONS
- Renal Transporters: OAT, OCT, MRP transporter activity
- Proximal Tubule Toxicity: Aminoglycoside, cisplatin nephrotoxicity
- Glomerular Filtration: Podocyte injury and proteinuria
- PKD Modeling: Polycystic kidney disease cyst formation