MARKET LEADERSHIP
Liver models represent the most mature and widely adopted segment of human simulation technologies. Drug-induced liver injury (DILI) is the leading cause of drug withdrawal and clinical trial failure, driving pharmaceutical investment in predictive liver platforms.
PLATFORM TYPES
- Liver-Chip: Emulate's FDA ISTAND-qualified platform (87% DILI sensitivity)
- Liver Spheroids: InSphero 3D InSight microtissues
- Liver Organoids: HUB/Merck cholangiocyte and hepatocyte organoids
- Multi-Organ: CN Bio gut-liver axis for first-pass metabolism
KEY APPLICATIONS
- DILI Prediction: Hepatotoxicity risk assessment
- Drug Metabolism: CYP450 enzyme induction/inhibition
- ADME Studies: Absorption, distribution, metabolism, excretion
- Disease Modeling: NASH, NAFLD, viral hepatitis, fibrosis